Acrolein exposure suppresses antigen-induced pulmonary inflammation

Acrolein exposure suppresses antigen-induced pulmonary inflammation

BACKGROUND Adverse health effects of tobacco smoke arise partly from its influence on innate and adaptive immune responses, leading to impaired innate immunity and host defense. The impact of smoking on allergic asthma remains unclear, with various reports demonstrating that cigarette smoke enhances asthma development but can also suppress allergic airway inflammation. Based on our previous fin...

Acrolein Reference Exposure Levels

Acrolein is a powerful irritant. Due to its highly reactive nature, the effects of acrolein are generally limited to the site of contact; skin, eyes and mucous membranes. Inhalation exposure to low levels (≤ 1 ppm) causes irritation of the eyes, nose and throat. Acute exposures to levels above 1 ppm result in mucous hypersecretion and exacerbation of allergic airway response in animal models. M...

Acrolein Reference Exposure Levels

Acrolein is a powerful irritant. Due to its highly reactive nature, the effects of acrolein are generally limited to the site of contact; skin, eyes and mucous membranes. Inhalation exposure to low levels (≤ 1 ppm) causes irritation of the eyes, nose and throat. Moderately higher exposures may result in severe lacrimation, and irritation of the mucous membranes of the respiratory tract. Death d...

maternal nicotine exposure-induced collagen pulmonary changes

nicotine is an alkaloid by high level of addictive property that can quickly assimilate from smoker’s lung. it passes from the placenta and gathers in the developing fetus. our previous study showed that collagen type iv plays a critical role in basement membrane of different embryonic organs. in this study the effect of maternal nicotine was evaluated by collagen iv changes in lung of mice off...

Acute Airways Neutrophilia Cytokine Production but Does Not Affect Lipopolysaccharide-Induced Inflammatory Acrolein Inhalation Suppresses